ONE bite from a black mamba
can kill a person within half an hour. Strangely though, venom from
what's arguably the world's deadliest snake could actually be a
painkiller on a par with morphine.
In search of a new analgesic, Anne
Baron at the Institute of Molecular and Cellular Pharmacology in
Valbonne, France, and her colleagues, hunted through hundreds of
compounds for one that blocks acid-sensing ion channels in nerves. These
are key in a common pain pathway. The successful compound turned out to
be venom from a black mamba.
Baron's team then identified which
proteins in the venom blocked the ion channels, before naming them
mambalgins and purifying them to produce a drug.
Mice injected with the drug appeared to be significantly more resilient to pain compared with those given a sham treatment (Nature, DOI: 10.1038/nature11494).
The drug did not affect the opioid receptors that are targeted by morphine but was just as effective in relieving pain.
Anyone taking the new drug might
therefore avoid side effects associated with morphine, which include
addiction and breathing problems, says Baron.
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